aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. PDF Iron dosing and administration in adults backgrounder Use Caution/Monitor. Parenteral iron dextran therapy: a review. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. Use Caution/Monitor. IV iron products (adults) - UpToDate PDF GUIDELINES FOR IRON INFUSION USE IN ADULTS - Brockville General Hospital Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. Calcs that help predict probability of a disease, Subcategory of 'Diagnosis' designed to be very sensitive, Disease is diagnosed: prognosticate to guide treatment. Modify Therapy/Monitor Closely. Compare formulary status to other drugs in the same class. This site contains information for licensed healthcare professionals in the United States. Applies only to oral form of both agents. Applies only to oral form of both agents. feasible, Maximum total cumulative iron sucrose dose administered in 14 days is 1000 mg elemental iron. Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . Iron Injection Administration | INJECTAFER HCP Venofer treatment may be repeated if necessary. Avoid or Use Alternate Drug. FERAHEME Dosing & Administration - Feraheme FERAHEME has flexible dosing for your patients FERAHEME flexible scheduling gives your patients the freedom to receive the iron they need as early as 3 days apart 1 FLEXIBLE DILUTION OPTIONS 1 Dilute full contents of vial (17 mL) in 50 mL to 200 mL of: 0.9% NaCl, or 5% dextrose STORAGE 1 Applies only to oral form of both agents. Available for Android and iOS devices. Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Parenteral iron dose - UpToDate Due Date form Ultrasound Report. Iron Deficiency Anemia: Periodic hematologic determination (hemoglobin and hematocrit) is a simple and accurate technique for monitoring hematological response, and should be used as a guide in therapy. Monitor for signs and symptoms of hypotension following each administration of Venofer. Venofer Dosing and Administration DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. Hemoglobin there are two fields for hemoglobin input, one for the target and another for actual value. Applies only to oral form of both agents. however iron sucrose requires multiple small intermittent doses over days to weeks. FERAHEME vs Venofer (iron sucrose) - Feraheme Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Applies only to oral form of both agents. provider for the most current information. Before using, check this product visually for particles or discoloration. Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. Taking the case of a patient weighing 75 kg (165.3 lbs) with a target hemoglobin value of 13 g/dL (130 g/L or 8.07 mmol/L), an actual hemoglobin of 9.5 g/dL (95 g/L or 5.9 mmol/L) and iron stores of 500 mg, the iron deficit is: Iron deficit = 75 x (13 9.5) x 2.4 + 500 = 1,130 mg. 2010;18(3). 4. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. Your doctor will do laboratory tests to monitor your response. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Each mL contains 20 mg of elemental . Iron Deficiency Calculator - MDApp ONE DOSE. 1000 mg. 20 MINUTES. Dosage Calculator We'll do this entirely for free, as long as the calculator has applications for women's health. Deferoxamine chelates iron. https://www.uptodate.com/ (Requires subscription). Applies only to oral form of both agents. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Use Caution/Monitor. Anemias. Intravenous iron replacement can take place as total dose (as in the case of iron-dextran or iron carboxymaltose) or as split dose (in the case of iron sucrose). The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Iron replenishment can be done intravenously, either as total dose (example: iron-dextran or iron carboxymaltose) or as split dose (example: iron sucrose). Controlled studies in pregnant women show no evidence of fetal risk. Fatal reactions have followed the test dose of iron dextran injection. Modify Therapy/Monitor Closely. Iron Sucrose - SlideShare This website is intended for use by US healthcare professionals only. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Am J Kid Dis 2001; 38 988991. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Consult your pharmacist or local waste disposal company. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. All you have to do is use the following formula: Liquid\ dose = Dose / Medicine\ concentration Liquid dose = Dose/M edicine concentration. Excessive therapy with parenteral iron can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. . Indicated for treatment of iron deficiency anemia associated with chronic kidney disease, Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week, Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period), Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week), Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease, <2 years: Safety and efficacy not established, Iron replacement treatment in pediatric patients has not been established. In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Intravenous iron sucrose for children with iron deficiency failing to Serious - Use Alternative (1)iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Monitor Closely (1)famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. (3) Known hypersensitivity to Venofer. Applies only to oral form of both agents. PDF Venofer - Food and Drug Administration omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. Iron Deficiency In Pregnancy Calculator, Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator. Always ask your health care professional for complete information about this product and your specific health needs. Crown Rump Length and Nuchal Translucency. The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. and formulary information changes. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. Monitor Closely (1)trientine, iron sucrose. Test Dose: Not required. Am J HealthSyst Pharm 2006;63:731735. Can't find what you need? Finally, a 400-mg dose by 2-hour infusion was examined in 35 patients, but 2 patients experienced such symptoms as hypotension, nausea, and lower back pain. Administer Venofer early during the dialysis session (generally within the first hour). Last updated on Jun 1, 2022. Applies only to oral form of both agents. Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. Avoid or Use Alternate Drug. iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L). Human studies not conducted. Applies only to oral form of both agents. Applies only to oral form of both agents. iron sucrose decreases levels of minocycline by inhibition of GI absorption. Use Caution/Monitor. calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Creating an account is free and takes less than 1 minute. Monitor Closely (1)sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. MDCalc loves calculator creators researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. Applies only to oral form of both agents. . Venofer treatment may be repeated if necessary. IMPORTANT SAFETY INFORMATION DOSAGE AND ADMINISTRATION Pediatric Patients (2 Years of Age and Older) Applies only to oral form of both agents. Treatment of anemia due to iron deficiency. Avoid or Use Alternate Drug. ADMINISTER THE TEST DOSE AT A GRADUAL RATE OVER AT LEAST 30 SECONDS. Slowing the infusion rate may alleviate symptoms. Administer Venofer only intravenously by slow injection or by infusion. Nutr Clin Pract. iron sucrose increases levels of calcium acetate by enhancing GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. No additional iron to replenish stores. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Administer a test INFeD dose prior to the first therapeutic dose. Administer Venofer early during the dialysis session (generally within the first hour). Do not administer Venofer to patients with iron overload. Use Caution/Monitor. Applies only to oral form of both agents. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. Iron Sucrose Dosage Guide + Max Dose, Adjustments - Drugs.com Parenteral Iron Replacement For Iron Deficiency Anemia Calculator Treatment of anemia due to iron deficiency. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . 1982;13(4):309-21. iron sucrose increases levels of calcium citrate by enhancing GI absorption. Applies only to oral form of both agents. IV iron sucrose (Venofer) given as divided dosages, and low molecular weight iron dextran (CosmoFer) this can be given as divided dose or as a total dose infusion . Sodium ferric gluconate (Ferrlecit) 62.5 mg . Ganzoni AM. Minor/Significance Unknown. Fatal reactions have also occurred in situations where the test dose was tolerated. Ferrlecit may be diluted in 100 mL of 0.9% sodium chloride administered by intravenous infusion over 1 hour per dialysis session. Uses for Iron Sucrose For patients weighing less than 50 kg (110 lb): Give Injectafer in two doses separated by at least 7 days. Applies only to oral form of both agents. Minor (1)iron sucrose, captopril. Use Caution/Monitor. Iron sucrose (Venofer) 100 mg/5 mL vial 200 - 300 mg given every 3-7 days 300 mg doses are given over 90 minutes 500 mg/dose. calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. Use Caution/Monitor. Mean change in Hgb from baseline to Week 5 2,5 Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. Applies only to oral form of both agents. The primary endpoint was the proportion of patients with . Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Recommended dosing and infusion rates for PI. Medicinal forms iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Written by ASHP. Jacobs P, Dommisse J. IDA symptoms are often nonspecific and include tiredness, weakness, shortness of breath. Applies only to oral form of both agents. Information last revised December 2022. Minor/Significance Unknown. Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator, Red Blood Cell (RBC) Indices Calculator, Iron Deficiency In Pregnancy Calculator. Monofer 100mg/ml solution for injection/infusion - Summary of Product You are encouraged to report Adverse Drug Events to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Modify Therapy/Monitor Closely. 1988 May;111(5):566-70. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Use Caution/Monitor. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Use Caution/Monitor. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows: Adults and Children over 15 kg (33 lbs): See Dosage Table. May increase risk of hypotension. The dosing of Monofer was performed according to the Simplified Table as described in section 4.2 above and dosing of iron sucrose was calculated according to Ganzoni and administered as 200 mg infusions. Separate dosing of tetracyclines from these products. Serious - Use Alternative (1)iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Each costs about $0.46 to $0.55 per mg of iron. Corrected Sodium and Effective Osmolality. Interaction only with oral iron administration. Iron sucrose | Drugs | BNF | NICE Venofer treatment may be repeated if iron deficiency reoccurs. iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet. Prescribing and dispensing information For iron sucrose A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. Applies only to oral form of both agents. Applies only to oral form of both agents. Kumpf VJ, Holland EG. Iron Deficiency Calculator ------------------------------------------------------------------------- Iron Dextran Complex [ Infed ] Elemental iron: 50 mg of elemental iron per mL [2 mL] [package insert] BOXED WARNING: WARNING: RISK FOR ANAPHYLACTIC-TYPE REACTIONS Anaphylactic-type reactions, including fatalities, have followed the parenteral administration of iron dextran injection. Minor/Significance Unknown. All Rights Reserved. If you log out, you will be required to enter your username and password the next time you visit. Observed Hb = the patients current hemoglobin in g/dl. Applies only to oral form of both agents. US residents can call their local poison control center at 1-800-222-1222. In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. Modify Therapy/Monitor Closely. The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product that meets the needs of the patient. Use Caution/Monitor. This health tool computes the required parenteral iron replacement dose for the iron deficit extracted from the patient weight and hemoglobin level from complete blood count test. Minor/Significance Unknown. Either increases effects of the other by pharmacodynamic synergism. Anemia. Otherwise, call a poison control center right away. https://www.uptodate.com/ (Requires subscription). INFeD is given undiluted at a slow gradual rate not to exceed 50 mg (1 mL) per minute. Applies only to oral form of both agents. Applies only to oral form of both agents. . Most reactions associated with intravenous iron preparations occur within 30 minutes of the completion of the infusion. Drug Dosing in Obesity Reference Table - ClinCalc.com Modify Therapy/Monitor Closely. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. Applies only to oral form of both agents. The iron deficit calculator is useful as one of the determinations performed before iron replenishment therapy is initiated. If either is present, do not use the liquid. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs.
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